Muscle Remodeling
This research focuses on muscle plasticity in response to environmental and energetic stress and how this impacts on whole-animal performance. For this purpose we use rodent models from different environments and the adult zebrafish as a model system to investigate molecular and biochemical aspects of vertebrate skeletal muscle and heart remodelling. Image from: Mahalingam et al., 2017. J. Physiol.
Sample publications:
Mahalingam, S., McClelland, G.B., and Scott, G.R. (2017) Evolved changes in the intracellular distribution and physiology of muscle mitochondria in high-altitude native deer mice. J. Physiol. (London) 595(14): 4785–4801.
McClelland, G.B., and Scott, G.R. (2013) Muscle Plasticity. In: Evans, DH, Claiborne, J.B., and Currie, S (eds.). The Physiology of Fishes, 4th ed. CRC press, Baton Raton, Fl.
McClelland, G.B. (2012) Muscle Remodeling and the Exercise Physiology of Fish. Exerc. Sport Sci. Rev. 40(3):165-173.
Schippers, M.-P., Dukas, R., and McClelland, G.B. (2010) Lifetime changes in flight metabolic rate and muscle biochemistry of honeybees, Apis mellifera. J. Comp. Physiol. B. 180(1):45-55.
McClelland, G.B., Craig, P.M., Dhekney, K and Dipardo, S. (2006) Temperature- and exercise-induced gene expression and metabolic enzyme changes in skeletal muscle of adult zebrafish (Danio rerio). J. Physiol. (London), 577(2):739-751.
Funding:
Research in the McClelland Lab is currently being funded by the National Sciences and Engineering Council (NSERC), the collaborations funded through NSF and NIH.
