Oxidative Stress and Toxigenomics
Animals face high levels of oxidative stress due to anthropomorphic increased in pollutants in their environment. We have used zebrafish, lamprey, killifish, mussels, and crabs as a model species to extend the Biotic Ligand Model to chronic metal exposures (Cu) and to biochemical & genomic endpoints.
Sample publications:
Kulesza, A., Leonard, E.M., and McClelland, G.B. (2020) Influence of 96h sub-lethal copper exposure on aerobic scope and recovery from exhaustive exercise in killifish (Fundulus heteroclitus). Aquatic Toxicology. 218:105373
Craig, P.M., Wood, C.M., and McClelland, G.B. (2010) Water Chemistry alters gene expression and physiological endpoints of chronic waterborne copper exposure in zebrafish, Danio rerio. Environ. Sci. Tech. 44: 2156-2162
Craig, P.M., Wood, C.M., and McClelland, G.B. (2007) Oxidative stress response and gene expression with acute copper exposure in zebrafish (Danio rerio). Am. J. Physiol. 293:R1882-R1892
Funding:
Research in the McClelland Lab has been funded by the National Sciences and Engineering Council (NSERC) CRD program and industrial partners.
